期刊
CLINICAL AND EXPERIMENTAL ALLERGY
卷 50, 期 10, 页码 1176-1183出版社
WILEY
DOI: 10.1111/cea.13711
关键词
environment; epidemiology; pediatrics
Background Allergic disease is a recognized global epidemic and a significant cause of ill health and poor quality of life. The prevalence of pollen allergy is high throughout the world, and pollen exposure itself plays a role in emergency department presentations and hospitalizations for asthma. Lung function and airway inflammation are important measures of asthma activity and control. Objective To examine associations between exposure to multiple pollen types and lung function and markers of airway inflammation at 8 and 14 years of age, and to explore potential modification by residential greenness. Methods A cohort of high-risk children living in Sydney, Australia had spirometry and fractional exhaled nitric oxide (FeNO) measured at 8 and 14 years of age. Ambient pollen concentration on the day of lung function measurement and up to three days prior was used as the exposure measure. Residential greenness was derived from satellite imagery. We modelled the association between six pollen types and lung function and FeNO. We also assessed modifying effects of residential greenness. Results Casuarina, cypress andPinuspollen in the air the day before measurement and 3 days prior respectively, were associated with reduced lung function in 8-year-olds. The pollen exposures were associated with decreases in FEV(1)and FVC; however, the FEV1/FVC ratio was not affected. Effect modification by greenness was not observed due to loss of power. Conclusions & Clinical Relevance Airborne tree pollen of cypress,CasuarinaandPinusand not grass in some regions may be detrimental to childhood lung function.
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