期刊
CHINESE JOURNAL OF CHEMISTRY
卷 38, 期 11, 页码 1233-1238出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.202000300
关键词
-
资金
- National Natural Science Foundation of China [21690063, 21572202, (Ra)-3cb, (Ra)-4ea]
Allenes are a class of very important compounds and the development of straightforward, efficient, and highly enantioselective synthetic strategies for allenes have attracted extensive interests. Along this line, it is well known that aryl-substituted allenes may be readily racemized, thus, difficult to prepare in high ee. Herein, an efficient palladium-catalyzed nucleophilic allenylation of malonates with racemic 4-aryl-2,3-butadienyl carbonates has been developed. The selectivity issue of mono-vs. bis-allenylation with 2-non-substituted malonates has been addressed. By utilizing (R)-(-)-DTBM-SEGPHOS (5,5'-bis[di(3,5-di-t-butyl-4-methoxyphenyl)phosphino]-4,4'-bi-1,3-benzodioxole) as a chiral ligand, various aryl-substituted allenes and bisallenes have been prepared with good to excellent yields with high chemoselectivity and enantioselectivity under mild reaction conditions. Au-catalyzed cycloisomerization and APK (allenic Pauson-Khand) reactions affording optically active mono- and bicyclic products have been demonstrated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据