期刊
CHINESE CHEMICAL LETTERS
卷 32, 期 2, 页码 721-724出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2020.07.007
关键词
Aqueous conditions; One-pot two-step process; Benzenesulfinic acid; Selenocarbamate; Allyl sulfone compound
资金
- National Natural Science Foundation of China [21971174, 21772137, 21672157]
- Ph.D. Programs Foundation of PAPD
- Project of Scientific and Technologic Infrastructure of Suzhou [SZS201708]
- Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions [16KJA150002]
- Soochow University
- State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials
This study reports a one-pot two-step reaction of selenosulfonate with isocyanides and allyl alcohol under aqueous conditions to afford selenocarbamates and allyl sulfone compounds. The method has advantages of being environmentally friendly, green, and having high atomic economy.
In many reactions involving selenosulfonate or thiosulfonate, the sulfone group often leaves in form of benzenesulfinic acid or sodium benzenesulfinate. A one-pot two-step reaction of selenosulfonate with isocyanides and allyl alcohol under aqueous conditions to afford selenocarbamates and allyl sulfone compounds is reported. The sulfinic acid as the first-step side product is converted to the allyl sulfone compound by water promoted reaction with allyl alcohol. Water acts as both an oxygen source of selenocarbamates and as a promoter to drive the second step reaction. The reactions have the advantages of mild conditions, green, environment-friendly, and high atomic economy. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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