期刊
CHEST
卷 158, 期 4, 页码 E147-E151出版社
ELSEVIER
DOI: 10.1016/j.chest.2020.06.005
关键词
CT; e-Cigarettes; MRI; vaping
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC) of Canada
- NSERC postdoctoral fellowship award
- NSERC
- Canadian Institutes of Health Research (CIHR)
Although nearly 3,000 e-cigarette-related hospitalizations have been reported in North America, the long-term outcomes in these patients have not been described. We followed an 18-year-old boy who survived acute critical illness and respiratory failure related to 5 months of e-cigarette use. Chronic irreversible airflow obstruction and markedly abnormal Xe-129 MRI ventilation heterogeneity was observed and persisted 8 months after hospital discharge, despite improvement in quality-of-life and chest CT findings. Lung clearance index and oscillometry measures were also highly abnormal at 8 months postdischarge. Although Xe-129 MRI ventilation abnormalities were dominant in the lung apices and central lung regions, the pattern of ventilation defects was dissimilar to ventilation heterogeneity observed in patients with obstructive lung disease, such as asthma and COPD. Our findings underscore the long-term functional impacts of e-cigarette-related lung injury in survivors of critical illness; longitudinal evaluations may shed light on the pathophysiologic mechanisms that drive e-cigarette-related lung disease.
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