期刊
CHEMPHYSCHEM
卷 21, 期 17, 页码 1905-1907出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.202000473
关键词
anomeric memory; IR spectroscopy; mass spectrometry; glycosylation; glycosyl cation
资金
- Max Planck Society
- Fonds National de la Recherche (FNR), Luxembourg [13549747]
- Fonds der Chemischen Industrie
- Alexander von Humboldt Foundation
- DFG InCheM [FOR 2177]
It has been reported that fragments produced by glycosidic bond breakage in mass spectrometry-based experiments can retain a memory of their anomeric configuration, which has major implications for glycan sequencing. Herein, we use cryogenic vibrational spectroscopy and ion mobility-mass spectrometry to study the structure of B-type fragments of protected galactosides. Cationic fragments were generated from glycosyl donors carrying trichloroacetimidate or thioethyl leaving groups of different anomeric configuration. The obtained infrared signatures indicate that the investigated fragments exhibit an identical structure, which suggests that there is no anomeric memory in B-type ions of fully protected monosaccharides.
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