期刊
CHEMOSPHERE
卷 252, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2020.126488
关键词
E-waste; Rare earth elements (REEs); Endocrine disruption; HPT axis; Thyroid gland
Rare earth elements (REEs) are widely used in electronic products. But the contaminations of REEs in the e-waste sites and the related health effects were barely investigated. In the present study, we analyzed the concentrations of REEs and the hormones of the HPT axis in plasma of subjects recruited from an e-waste area and a reference area in Taizhou, China. The results showed that the concentrations of several REEs like La, Ce were much higher in the exposed group than in the control group (all p < 0.001). The thyroid hormones, FT3 and FT4, and TRH showed no significant difference between the two groups, while the concentration of TSH was significantly higher in the exposed group when compared to the control group (p = 0.002). Separate regression analysis indicated that elevated La and Ce levels were associated with higher TSH concentrations. MDA and 8-iso, the biomarkers of oxidative stress, were also significantly higher in the exposed group than that of the control group (p = 0.002 and p = 0.003, respectively). The increased oxidative stress might be the mechanism underlying the disruptive effects of REEs on TSH. Our results indicated that the quantities of internal exposure of REEs in the subjects in the e-waste area were considerable and the compositional profile of the REEs in the exposed group was different from the control group due to the e-waste dismantling. The expression of TSH were also affected by high La and Ce exposure which showed an endocrine disruption effects of REEs on HPT axis. (C) 2020 Elsevier Ltd. All rights reserved.
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