相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Chemical and Biochemical Strategies To Explore the Substrate Recognition of O-GlcNAc-Cycling Enzymes
Chia-Wei Hu et al.
CHEMBIOCHEM (2019)
Evaluation of a PET Radioligand to Image O-GlcNAcase in Brain and Periphery of Rhesus Monkey and Knock-Out Mouse
Soumen Paul et al.
JOURNAL OF NUCLEAR MEDICINE (2019)
Computational Studies on the Potency and Selectivity of PUGNAc Derivatives Against GH3, GH20, and GH84 β-N-acetyl-D-hexosaminidases
Lili Dong et al.
FRONTIERS IN CHEMISTRY (2019)
Structural characterization of the O-GlcNAc cycling enzymes: insights into substrate recognition and catalytic mechanisms
Cassandra M. Joiner et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2019)
Discovery of Novel Inhibitors Targeting Human O-GlcNAcase: Docking-Based Virtual Screening, Biological Evaluation, Structural Modification, and Molecular Dynamics Simulation
Lili Dong et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)
Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies
Harold G. Selnick et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Novel glucopyranoside C2-derived 1,2,3-triazoles displaying selective inhibition of O-GlcNAcase (OGA)
Michelle O. Igual et al.
CARBOHYDRATE RESEARCH (2019)
Molecular mechanisms regulating O-linked N-acetylglucosamine (O-GlcNAc)-processing enzymes
Dustin T. King et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2019)
Diazaspirononane Inhibitors of O-GlcNAc Hydrolase for the Treatment of Central Nervous System Diseases
Gerard Rosse
ACS Medicinal Chemistry Letters (2019)
Early and Persistent O-GlcNAc Protein Modification in the Streptozotocin Model of Alzheimer's Disease
Joao Paulo Almeida dos Santos et al.
JOURNAL OF ALZHEIMERS DISEASE (2018)
Selective inhibition of β-N-acetylhexosaminidases by thioglycosyl-naphthalimide hybrid molecules
Wei Chen et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2018)
Design and synthesis of naphthalimide group-bearing thioglycosides as novel β-N-acetylhexosaminidases inhibitors
Shengqiang Shen et al.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2018)
Modification of the Thioglycosyl-Naphthalimides as Potent and Selective Human O-GlcNAcase Inhibitors
Shengqiang Shen et al.
ACS MEDICINAL CHEMISTRY LETTERS (2018)
Protein O-GlcNAcylation: emerging mechanisms and functions
Xiaoyong Yang et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode
Baobin Li et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
In situ click chemistry generation of cyclooxygenase-2 inhibitors
Atul Bhardwaj et al.
NATURE COMMUNICATIONS (2017)
Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode
Baobin Li et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
The emerging link between O-GlcNAcylation and neurological disorders
Xiaofeng Ma et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
O-GlcNAcylation: A regulator of tau pathology and neurodegeneration
Cheng-Xin Gong et al.
ALZHEIMERS & DEMENTIA (2016)
Synthesis of NAM-thiazoline derivatives as novel O-GlcNAcase inhibitors
Hanchu Kong et al.
CARBOHYDRATE RESEARCH (2016)
Dissecting PUGNAc-mediated inhibition of the pro-survival action of insulin
Chin Fen Teo et al.
GLYCOBIOLOGY (2016)
Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcase
N. Cekic et al.
CHEMICAL SCIENCE (2016)
A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors
Milan Bergeron-Brlek et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
A unique GCN5-related glucosamine N-acetyltransferase region exist in the fungal multi-domain glycoside hydrolase family 3 β-N-acetylglucosaminidase
Zhen Qin et al.
SCIENTIFIC REPORTS (2015)
O-GlcNAc transferase and O-GlcNAcase: achieving target substrate specificity
Alexis K. Nagel et al.
AMINO ACIDS (2014)
Thiamet-G-mediated inhibition of O-GlcNAcase sensitizes human leukemia cells to microtubule-stabilizing agent paclitaxel
Ning Ding et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
O-GlcNAc and neurodegeneration: biochemical mechanisms and potential roles in Alzheimer's disease and beyond
Scott A. Yuzwa et al.
CHEMICAL SOCIETY REVIEWS (2014)
Defining the structural origin of the substrate sequence independence of O-GlcNAcase using a combination of molecular docking and dynamics simulation
Joanne C. Martin et al.
GLYCOBIOLOGY (2014)
Nine of 16 Stereoisomeric Polyhydroxylated Proline Amides Are Potent β-N-Acetylhexosaminidase Inhibitors
Benjamin J. Ayers et al.
JOURNAL OF ORGANIC CHEMISTRY (2014)
Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice
Scott A. Yuzwa et al.
MOLECULAR NEURODEGENERATION (2014)
Inhibition of GlcNAc-Processing Glycosidases by C-6-Azido-NAG-Thiazoline and Its Derivatives
Jana Krejzova et al.
MOLECULES (2014)
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy
Danielle L. Graham et al.
NEUROPHARMACOLOGY (2014)
The carbohydrate-active enzymes database (CAZy) in 2013
Vincent Lombard et al.
NUCLEIC ACIDS RESEARCH (2014)
Synthesis of the enantiomers of XYLNAc and LYXNAc: comparison of β-N-acetylhexosaminidase inhibition by the 8 stereoisomers of 2-N-acetylamino-1,2,4-trideoxy-1,4-iminopentitols
Elizabeth V. Crabtree et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2014)
Inhibition of O-GlcNAcase (OGA): A Potential Therapeutic Target to Treat Alzheimer’s Disease
Ahmed F. Abdel-Magid
ACS Medicinal Chemistry Letters (2014)
O-GlcNAc Cycling: A Link Between Metabolism and Chronic Disease
Michelle R. Bond et al.
ANNUAL REVIEW OF NUTRITION, VOL 33 (2013)
Chemical tools to probe cellularO-GlcNAc signalling
Adam Ostrowski et al.
BIOCHEMICAL JOURNAL (2013)
O-linked beta-N-acetylglucosaminidase inhibitor attenuates beta-amyloid plaque and rescues memory impairment
Chaeyoung Kim et al.
NEUROBIOLOGY OF AGING (2013)
Increasing Brain Protein O-GlcNAc-ylation Mitigates Breathing Defects and Mortality of Tau.P301L Mice
Peter Borghgraef et al.
PLOS ONE (2013)
Cracking the O-GlcNAc code in metabolism
Hai-Bin Ruan et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)
Identification of a Specific Inhibitor of nOGA - a Caspase-3 Cleaved O-GlcNAcase Variant during Apoptosis
Jing Li et al.
BIOCHEMISTRY-MOSCOW (2012)
Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition
Marianne Schimpl et al.
CHEMISTRY & BIOLOGY (2012)
The Increase in O-Linked N-Acetylglucosamine Protein Modification Stimulates Chondrogenic Differentiation Both in Vitro and in Vivo
Jessica Andres-Bergos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation
Scott A. Yuzwa et al.
NATURE CHEMICAL BIOLOGY (2012)
Bittersweet memories: linking metabolism to epigenetics through O-GlcNAcylation
John A. Hanover et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation
Yang Yu et al.
PLOS ONE (2012)
Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses
Yuan He et al.
AMINO ACIDS (2011)
Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease
Gerald W. Hart et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)
Active-pocket size differentiating insectile from bacterial chitinolytic β-N-acetyl-D-hexosaminidases
Tian Liu et al.
BIOCHEMICAL JOURNAL (2011)
Design and synthesis of O-GlcNAcase inhibitors via 'click chemistry' and biological evaluations
Tiehai Li et al.
CARBOHYDRATE RESEARCH (2011)
O-GlcNAc signalling: implications for cancer cell biology
Chad Slawson et al.
NATURE REVIEWS CANCER (2011)
Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase
Matthew S. Macauley et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2010)
OGA inhibition by GlcNAc-selenazoline
Eun Ju Kim et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Synthesis and biological evaluation of glycal-derived novel tetrahydrofuran 1,2,3-triazoles by 'click' chemistry
L. Vijaya Raghava Reddy et al.
CARBOHYDRATE RESEARCH (2010)
Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases
Helge C. Dorfmueller et al.
CHEMISTRY & BIOLOGY (2010)
Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes
Matthew S. Macauley et al.
CHEMISTRY & BIOLOGY (2010)
Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds
Helge C. Dorfmueller et al.
FEBS LETTERS (2010)
Visualizing the Reaction Coordinate of an O-GlcNAc Hydrolase
Yuan He et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
A Selective Inhibitor Gal-PUGNAc of Human Lysosomal beta-Hexosaminidases Modulates Levels of the Ganglioside GM2 in Neuroblastoma Cells
Keith A. Stubbs et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
GIcNAcstatins are nanomolar inhibitors of human O-GIcNAcase inducing cellular hyper-O-GIcNAcylation
Helge C. Dorfmueller et al.
BIOCHEMICAL JOURNAL (2009)
GlcNAc-Thiazoline conformations
Spencer Knapp et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2009)
Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase
Yuan He et al.
CARBOHYDRATE RESEARCH (2009)
Enzymatic characterization and inhibition of the nuclear variant of human O-GlcNAcase
Matthew S. Macauley et al.
CARBOHYDRATE RESEARCH (2009)
Design, Synthesis, and Biological Evaluation of Enantiomeric β-N-Acetylhexosaminidase Inhibitors LABNAc and DABNAc as Potential Agents against Tay-Sachs and Sandhoff Disease
J. S. Shane Rountree et al.
CHEMMEDCHEM (2009)
Gem-diamine 1-N-iminosugars as versatile glycomimetics: synthesis, biological activity and therapeutic potential
Yoshio Nishimura
JOURNAL OF ANTIBIOTICS (2009)
Molecular Basis for Inhibition of GH84 Glycoside Hydrolases by Substituted Azepanes: Conformational Flexibility Enables Probing of Substrate Distortion
Filipa Marcelo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Probing Synergy between Two Catalytic Strategies in the Glycoside Hydrolase O-GlcNAcase Using Multiple Linear Free Energy Relationships
Ian R. Greig et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)
Loss of p53 enhances catalytic activity of IKKβ through O-linked β-N-acetyl glucosamine modification
Keiko Kawauchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Cu-catalyzed azide-alkyne cycloaddition
Morten Meldal et al.
CHEMICAL REVIEWS (2008)
Chemical dissection of the link between streptozotocin, O-GlcNAc, and pancreatic cell death
Shalini Pathak et al.
CHEMISTRY & BIOLOGY (2008)
Characterization of β-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis
Chutikarn Butkinaree et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Elevation of Global O-GlcNAc Levels in 3T3-L1 Adipocytes by Selective Inhibition of O-GlcNAcase Does Not Induce Insulin Resistance
Matthew S. Macauley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance
Xiaoyong Yang et al.
NATURE (2008)
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
Scott A. Yuzwa et al.
NATURE CHEMICAL BIOLOGY (2008)
Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB
Elizabeth Ficko-Blean et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Distinctive inhibition of O-GlcNAcase isoforms by an α-GlcNAc thiolsulfonate
Eun J. Kim et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Small molecule inhibitors of a glycoside hydrolase attenuate inducible AmpC-mediated β-lactam resistance
Keith A. Stubbs et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Tautomeric modification of GlcNAc-thiazoline
Spencer Knapp et al.
ORGANIC LETTERS (2007)
Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics
Nelly Khidekel et al.
NATURE CHEMICAL BIOLOGY (2007)
Cycling of O-linked β-N-acetylglucosamine on nucleocytoplasmic proteins
Gerald W. Hart et al.
NATURE (2007)
High-throughput screening for human lysosomal β-N-acetyl hexosaminidase inhibitors acting as pharmacological chaperones
Michael B. Tropak et al.
CHEMISTRY & BIOLOGY (2007)
Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase:: Mechanistic and structural insights into inhibitor selectivity and transition state poise
Garrett E. Whitworth et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
GlcNAcstatin:: A picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-GlcNAcylation levels
Helge C. Dorfmueller et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Modification of p53 with O-linked N-acetylglucosamine regulates p53 activity and stability
Won Ho Yang et al.
NATURE CELL BIOLOGY (2006)
Crystallographic structure of human β-hexosaminidase A:: Interpretation of Tay-Sachs mutations and loss of GM2 ganglioside hydrolysis
M. Joanne Lemieux et al.
JOURNAL OF MOLECULAR BIOLOGY (2006)
Enzymatic characterization of O-GlcNAcase isoforms using a fluorogenic GlcNAc substrate
Eun Ju Kim et al.
CARBOHYDRATE RESEARCH (2006)
An O-GlcNAcase-specific inhibitor and substrate engineered by the extension of the N-acetyl moiety
EJ Kim et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Structural insights into the mechanism and inhibition of eukaryotic O-GlcNAc hydrolysis
FV Rao et al.
EMBO JOURNAL (2006)
Structure and mechanism of a bacterial β-glucosaminidase having O-GlcNAcase activity
RJ Dennis et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Identification of Asp174 and Asp175 as the key catalytic residues of human O-GlcNAcase by functional analysis of site-directed mutants
N Çetinbas et al.
BIOCHEMISTRY (2006)
A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase
KA Stubbs et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2006)
Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor
Bhagavathy Shanmugasundaram et al.
CHEMICAL COMMUNICATIONS (2006)
Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: New structures for antivirals and osteoarthritis
PH Liang et al.
CHEMBIOCHEM (2006)
O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis
MS Macauley et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
O-GlcNAcase uses substrate-assisted catalysis -: Kinetic analysis and development of highly selective mechanism-inspired inhibitors
MS Macauley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Synthesis of N-acetylglucosamine-derived nagstatin analogues and their evaluation as glycosidase inhibitors
M Terinek et al.
HELVETICA CHIMICA ACTA (2005)
Characterization of the histone acetyltransferase (HAT) domain of a bifunctional protein with activable O-GlcNAcase and HAT activities
C Toleman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Crystal structure of human β-hexosaminidase B:: Understanding the molecular basis of Sandhoff and Tay-Sachs disease
BL Mark et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Streptozotocin, an O-GlcNAcase inhibitor, blunts insulin and growth hormone secretion
K Liu et al.
MOLECULAR AND CELLULAR ENDOCRINOLOGY (2002)
Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides
CW Tornoe et al.
JOURNAL OF ORGANIC CHEMISTRY (2002)
Recent developments of transition-state analogue glycosidase inhibitors of non-natural product origin
VH Lillelund et al.
CHEMICAL REVIEWS (2002)
Structural insights into the catalytic mechanism of a family 18 exo-chitinase
DMF van Aalten et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a β-N-acetylglucosaminidase
N Comtesse et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
Dynamic O-glycosylation of nuclear and cytosolic proteins -: Cloning and characterization of a neutral, cytosolic β-N-acetylglucosaminidase from human brain
Y Gao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Crystallographic evidence for substrate-assisted catalysis in a bacterial β-hexosaminidase
BL Mark et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Crystal structure of hyaluronidase, a major allergen of bee venom
Z Markovic-Housley et al.
STRUCTURE (2000)
Drug-like properties and the causes of poor solubility and poor permeability
CA Lipinski
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2000)
分享论文
