期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 58, 页码 13311-13316出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202002811
关键词
asymmetric hydrogenation; iridium catalysis; ketones; ligand development; N-heterocyclic carbene
资金
- Swedish Research Council (VR)
- Stiftelsen Olle Engkvist Byggmastare
- Swedish Energy Agency
- SYNFLOW (FP7)
- Knut and Alice Wallenberg foundation [KAW 2016:0072, 2018:0066]
- Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Thailand
Novel bidentate N-heterocyclic carbene-phosphine iridium complexes have been synthesized and evaluated in the hydrogenation of ketones. Reported catalytic systems require base additives and, if excluded, need elevated temperature or high pressure of hydrogen gas to achieve satisfactory reactivity. The developed catalysts showed extremely high reactivity and good enantioselectivity under base-free and mild conditions. In the presence of 1 mol % catalyst under 1 bar hydrogen pressure at room temperature, hydrogenation was complete in 30 minutes giving up to 96 % ee. Again, this high reactivity was achieved in additive-free conditions. Mechanistic experiments demonstrated that balloon pressure of hydrogen was sufficient to form the activate species by reducing and eliminating the 1,5-cyclooctadiene ligand. The pre-activated catalyst was able to hydrogenate acetophenone with 89 % conversion in 5 min.
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