Ladderane Natural Products: From the Ground Up

The ladderane family of natural products are well known for their linearly concatenated cyclobutane skeletal structure. Owing to their unique carbocyclic framework, several chemical syntheses have been reported since their discovery in 2002. The focus of this review is to showcase the novel tactics that have been used to generate the ladderane core and the challenges that are associated with the synthesis of these unusual and complex natural products.

Automated summary

The ladderane family of natural products is famous for their linearly concatenated cyclobutane skeletal structure, and since their discovery in 2002, several chemical syntheses have been reported. This review focuses on showcasing the novel tactics used to generate the ladderane core and the challenges associated with synthesizing these unusual and complex natural products.