期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 56, 页码 12846-12861出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202001752
关键词
cancer; drug design; ligand design; platinum; rhenium
资金
- Sorbonne Universite
- CNRS
The two independentON<^>O andNN<^>coordination sites of a newly synthesized bis[2-(hydroxyphenyl)-1,2,4-triazole] platform have been exploited to prepare four monometallic neutral (ON<^>O)Pt(II)complexes carrying DMSO, pyridine, triphenylphosphine, or N-heterocyclic carbene as the fourth ligand. Then, the secondNN<^>coordination site was used to introduce an IR-active rhenium tricarbonyl entity, affording the four corresponding heterobimetallic neutral Pt-II/Re(I)complexes, as well as a cationic Pt-II/Re(I)derivative. X-ray crystallographic studies showed that distortion of the organic platform occurred to accommodate the coordination geometry of both metal centers. No ligand exchange or transchelation occurred upon incubation of the Pt(II)complexes in aqueous environment or in the presence of Fe-III, respectively. The antiproliferative activity of the ligand and complexes was first screened on the triple-negative breast cancer cell line MDA-MB-231. Then, the IC(50)values of the most active candidates were determined on a wider panel of human cancer cells (MDA-MB-231, MCF-7, and A2780), as well as on a nontumorigenic cell line (MCF-10A). Low micromolar activities were reached for the complexes carrying a DMSO ligand, making them the first examples of highly active, but hydrolytically stable, Pt(II)complexes. Finally, the characteristic mid-IR signature of the {Re(CO)(3)} fragment in the Pt/Re heterobimetallic complexes was used to quantify their uptake in breast cancer cells.
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