Ligand-Enabled Palladium-Catalyzed Through-Space C-H Bond Activation via a Carbopalladation/1,4-Pd Migration/C-H Functionalization Sequence

We report, herein, a palladium-catalyzed cascade comprising carbopalladation, 1,4-Pd-migration and C(sp(2))-C(sp(2)) bond formation to construct a variety of bis-heterocyclic frameworks in a single operational step. The methodology provides a direct approach to introduce an oxadiazole core at a remote location without any functional group obligation, with moderate to good yields.