期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 26, 期 66, 页码 15084-15088出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.202001802
关键词
controlled release; delivery; hydrolysis; multimodal; nanogel
资金
- China Scholarship Council (CSC) [201706890012]
- Abel Tasman Talent Program (GSMS-UMCG)
- Dutch Technology Foundation TTW of The Netherlands Organization for Scientific Research (NWO)
A multimodal approach for hydrogel-based nanoparticles was developed to selectively allow molecular conjugated species to either be released inside the cell or remain connected to the polymer network. Using the intrinsic difference in reactivity between esters and amides, nanogels with an amide-conjugated dye could be tracked intracellularly localizing next to the nucleus, while ester-conjugation allowed for liberation of the molecular species from the hydrogel network inside the cell, enabling delivery throughout the cytoplasm. The release was a result of particle exposure to the intracellular environment. The conjugation approach and polymer network building rely on the same chemistry and provide a diverse range of possibilities to be used in nanomedicine and theranostic approaches.
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