期刊
CHEMICAL RECORD
卷 20, 期 9, 页码 989-1016出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.202000066
关键词
alpha-aminonitriles; natural products; total synthesis; amines; sustainable chemistry
Due to their numerous reactivity modes, alpha-aminonitriles represent versatile and valuable building blocks in organic total synthesis. Since their discovery by Adolph Strecker in 1850, this compound class has seen a wide dissemination in synthetic applications from laboratory to million-ton industrial scale and was extensively used in the syntheses of various classes of natural products. As these compounds provide a multitude of reactivity options, we feel that a broad overview of their multiple reaction modes may reveal less familiar opportunities for successful total synthesis planning. This personal account article will thus focus on alpha-aminonitriles used as key intermediates in selected natural product synthesis sequences which have been reported in the two decades since Enders' and Shilvock's seminal review. Natural alpha-aminonitriles will also briefly be treated.
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