期刊
CHEMICAL ENGINEERING JOURNAL
卷 390, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2020.124621
关键词
Titanium implants; ZIF-8; Levo; Antibacterial coating; Osteogenesis
资金
- National Natural Science Foundation of China [51825302, 21734002, 31700827, 51673032]
- State Key Project of Research and Development [2016YFC1100300, 2017YFB0702603]
- Natural Science Foundation of Chongqing Municipal Government [CXTDX201601002]
- China Postdoctoral Science Foundation [2017M622971, 2018T110946]
- Innovation Team in University of Chongqing Municipal Government [CXTDX201601002]
- Fundamental Research Funds for the Central Universities [10611CDJXZ238826]
Bone implant-associated infection is one of the major concerns in orthopedics, and may even result in implant failure. To this end, we developed a strategy for the fabrication of an antibacterial coating on titanium (Ti) implants with pH-response to combat bacteria-mediated acidification of the local microenvironment. It includes three steps: first, we synthesized levofloxacin (Levo)-loaded zeolitic imidazolate framework-8 (ZIF-8@Levo) nanoparticles; second, the nanoparticles were loaded onto the collagen-modified Ti substrates by the cathode electrophoresis deposition (EPD) method; third, gelatin (Gel) and chitosan (Chi) multilayers were spin-coated on the modified Ti substrates, since the chelating effect of Gel and Chi would reduce the hydrolysis of ZIF-8@Levo for a sustained release of Levo and Zn2+. The fabricated samples of MOF@Levo/LBL promoted in vitro adhesion, proliferation, and differentiation of osteoblasts. Moreover, the MOF@Levo/LBL samples exhibited strong antibacterial ability against Escherichia coli and Staphylococcus aureus through hydrolysis of ZIF-8 nanoparticles, thereby creating a marginally alkaline microenvironment. Furthermore, in vivo implantation in a femur-infected rat model revealed that MOF@Levo/LBL implants effectively inhibited bacterial adhesion, apart from significantly improving osseointegration of the Ti implants. The study provides a promising alternative for fabricating multifunctional Ti implants with strong antibacterial capacity and enhanced bone formation for potential orthopedic application.
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