期刊
CHEMICAL ENGINEERING JOURNAL
卷 390, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2020.124312
关键词
Black phosphorus; Heat shock protein; Photothermal therapy; NIR-responsive; Synergism
资金
- National Natural Science Foundation of China (NSFC) [U1605225, 81971734, 31800794]
- Program for Innovative Research Team in Science and Technology in Fujian Province University
- Subsidized Project for Cultivating Postgraduates' Innovative Ability in Scientific Research of Huaqiao University
- Brigham Research Institute
In an attempt to attain synergistic therapeutic benefits and address various intrinsic limitations of the highly efficient black phosphorus quantum dots (BPQDs), we fabricated poly((L)-lactide)-poly(ethylene glycol)-poly((L)-lactide) triblock copolymer (PLLA-PEG-PLLA)-based nanocomposites co-loaded with BPQDs and gambogic acid (GA) using the supercritical carbon dioxide (SC-CO2) technology to achieve photoacoustic (PA) imaging-guided synergistic chemo-photothermal therapy. On the one hand, BPQDs displayed near-infrared (NIR)-induced hyperthermia through the high photothermal conversion efficiency. On the other hand, the NIR-responsive release of GA facilitated early apoptosis through specific binding to stress-induced overexpression of heat shock protein (HSP)-90 for combating thermoresistant tumor cells. GA significantly promoted the photothermal therapy (PTT) efficiency by enhancing both early and late apoptosis of BPQDs. Moreover, the encapsulation of BPQDs in the polymer significantly improved their chemical as well as photothermal stabilities. Our findings suggested that these nanocomposites fabricated using the eco-friendly supercritical fluid (SCF) technology provided good protection to the biodegradable BPQDs, offering a great potential towards cancer ablation through augmented synergistic effects.
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