期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 68, 期 7, 页码 671-674出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.c20-00080
关键词
Artocarpus lakoocha; cytotoxic activity; antimycobacterial activity; antiplasmodial activity
资金
- Science Achievement Scholarship of Thailand
- Graduate School, Chiang Mai University
- Office of the Higher Education Commissions [MRG5980004]
- Thailand Research Fund [MRG5980004]
- Chiang Mai University
Chromatographic separation of the acetone extracts from the twigs and barks of Artocarpus lakoocha led to the isolation of the one new flavanone, lakoochanone (1), together with eleven known compounds (2-12). Lakoochanone (1) and moracin C (4) exhibited weak antiplasmodial activity against Plasmodium falciparum Dd2 w ith IC50 values of 36.7 and 33.9 mu M, respectively. Moreover, moracin C (4) and sanggenofuran B (5) showed cytotoxic activity against A2780 cell line with the respective IC50 values of 15.0 and 57.1 mu M. In addition, cyclocommunin (7) displayed strong antimycobacterial activity against Mycobacterium tuberculosis H37Ra with the minimum inhibitory concentration (MIC) value of 12.3 mu M.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据