期刊
CHEMBIOCHEM
卷 22, 期 2, 页码 264-287出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.202000354
关键词
alkaloids; enzyme catalysis; metabolism; structural biology; synthetic biology
资金
- Alberta Applied Agricultural Genomics Program grant from Genome Alberta [A3GP16]
- Strategic Project Grant from Alberta Innovates [G2018000889]
PR10/Bet v1-like proteins, a subset of PR proteins, play key roles in plant specialized metabolism by binding a wide range of lipophilic ligands.
Pathogenesis-related (PR) proteins constitute a broad class of plant proteins with analogues found throughout nature from bacteria to higher eukaryotes. PR proteins were first noted in plants as part of the hypersensitive response, but have since been assigned an array of biological roles. The PR10/Bet v1-like proteins are a subset of PR proteins characterized by an ability to bind a wide range of lipophilic ligands, uniquely positioning them as contributors to specialized biosynthetic pathways. PR10/Bet v1-like proteins participate in the production of plant alkaloids and phenolics including flavonoids, both as general binding proteins and in special cases as catalysts. Owing initially to the perceived allergenic properties of PR10/Bet v1-like proteins, many were studied at the structural level to elucidate the basis for ligand binding. These studies provided a foundation for more recent efforts to understand higher-level structural order and how PR10/Bet v1-like proteins catalyse key reactions in plant pathways. Synthetic biology aimed at reconstituting plant-specialized metabolism in microorganisms uses knowledge of these proteins to fine-tune performance in new systems.
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