期刊
CHROMOSOMA
卷 126, 期 1, 页码 73-81出版社
SPRINGER
DOI: 10.1007/s00412-016-0613-6
关键词
Cytogenomics; Supernumerary chromosomes; Genomics; Evolution
资金
- Sao Paulo Research Foundation [13/04533-3]
- National Council for Scientific and Technological Development [474684/2013-0, 301728/2011-9]
- Sao Paulo State University [0045/021/13-PROPe/CDC]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [13/04533-3] Funding Source: FAPESP
Though hundreds to thousands of reports have described the distribution of B chromosomes among diverse eukaryote groups, a comprehensive theory of their biological role has not yet clearly emerged. B chromosomes are classically understood as a sea of repetitive DNA sequences that are poor in genes and are maintained by a parasitic-drive mechanism during cell division. Recent developments in high-throughput DNA/RNA analyses have increased the resolution of B chromosome biology beyond those of classical and molecular cytogenetic methods; B chromosomes contain many transcriptionally active sequences, including genes, and can modulate the activity of autosomal genes. Furthermore, the most recent knowledge obtained from omics analyses, which is associated with a systemic view, has demonstrated that B chromosomes can influence cell biology in a complex way, possibly favoring their own maintenance and perpetuation.
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