期刊
CERAMICS INTERNATIONAL
卷 46, 期 10, 页码 16708-16715出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2020.03.245
关键词
beta-tricalcium phosphate; Powders: chemical preparation; Electron microscopy; Biomedical applications
资金
- Ministry of Science and Technology of Taiwan, Taiwan [MOST 106-2221-E-011-049, 108-2923-E-011 -007 -MY3]
Beta-tricalcium phosphate (beta-TCP) has been applied in the fields of medical science owing to its osteoconductive properties which stimulate the growth of new bones. However, the material itself lacks of antibacterial properties which limits its applications. Thus, in this study antibacterial beta-TCP specimens were proposed by Ag and Zn dopant. Preparation method of one-step spray pyrolysis was used with advantages of low contamination and continuous production over the sol-gel and wet chemical precipitation synthesis. The crystallographic structure, morphology and chemical composition of un-doped, Ag-doped and Ag/Zn co-doped beta-TCP were characterized by X-ray diffraction, scanning electron microscopy, energy dispersive spectroscopy and transmission electron microscopy, respectively. Furthermore, the antibacterial activity against Escherichia coli was examined by colony count method. Finally, two dominant formation mechanisms were discussed and the antibacterial results indicate that the addition of Zinc nitrate precursor can enhance the activity of Ag/Zn co-doped beta-TCP specimen.
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