期刊
CELL PROLIFERATION
卷 53, 期 9, 页码 -出版社
WILEY
DOI: 10.1111/cpr.12874
关键词
angiogenesis; coupling; micro-vessels; osteogenesis; type H endothelium
类别
资金
- National Natural Science Foundation of China [81971319, 81571366]
Coupling between angiogenesis and osteogenesis has an important role in both normal bone injury repair and successful application of tissue-engineered bone for bone defect repair. Type H blood vessels are specialized microvascular components that are closely related to the speed of bone healing. Interactions between type H endothelial cells and osteoblasts, and high expression of CD31 and EMCN render the environment surrounding these blood vessels rich in factors conducive to osteogenesis and promote the coupling of angiogenesis and osteogenesis. Type H vessels are mainly distributed in the metaphysis of bone and densely surrounded by Runx2(+)and Osterix(+)osteoprogenitors. Several other factors, including hypoxia-inducible factor-1 alpha, Notch, platelet-derived growth factor type BB, and slit guidance ligand 3 are involved in the coupling of type H vessel formation and osteogenesis. In this review, we summarize the identification and distribution of type H vessels and describe the mechanism for type H vessel-mediated modulation of osteogenesis. Type H vessels provide new insights for detection of the molecular and cellular mechanisms that underlie the crosstalk between angiogenesis and osteogenesis. As a result, more feasible therapeutic approaches for treatment of bone defects by targeting type H vessels may be applied in the future.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据