期刊
CELL HOST & MICROBE
卷 28, 期 2, 页码 233-244出版社
CELL PRESS
DOI: 10.1016/j.chom.2020.07.007
关键词
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资金
- DFG [LA 4286/1-1]
- NIH [R01 AA020703, R01 AA24726, U01 AA026939, P30 DK120515, P50 AA011999]
- Biomedical Laboratory Research & Development Service of the VA Office of Research and Development [BX004594]
The liver communicates with the intestine via the portal vein, biliary system, and mediators in the circulation. Microbes in the intestine maintain liver homeostasis but can also serve as a source of pathogens and molecules that contribute to fatty liver diseases. We review changes in the gut microbiota that can promote development or progression of alcohol-associated and non-alcoholic fatty liver disease-the most common chronic diver diseases in Western countries. We discuss how microbes and their products contribute to liver disease pathogenesis, putative microbial biomarkers of disease, and potential treatment approaches based on manipulation of the gut microbiota. Increasing our understanding of interactions between the intestinal microbiome and liver might help us identify patients with specific disease subtypes and select specific microbiota-based therapies.
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