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Liyao Xu et al.
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OpenMS - A platform for reproducible analysis of mass spectrometry data
Julianus Pfeuffer et al.
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KNIME for reproducible cross-domain analysis of life science data
Alexander Fillbrunn et al.
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Zhixian Liu et al.
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Chiara Francavilla et al.
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Yi-Ting Wang et al.
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Danica D. Wiredja et al.
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Ariane Marumoto et al.
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Matthew The et al.
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Hannes L. Roest et al.
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Bryn S. Moore et al.
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Florian Gnad et al.
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Kai Chen et al.
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The kinome 'at large' in cancer
Emmy D. G. Fleuren et al.
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Xuesong Zhao et al.
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Marcelo Chavez et al.
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Francesc R. Garcia-Gonzalo et al.
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Louise von Stechow et al.
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Matthew E. Ritchie et al.
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Elisabetta Rovida et al.
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Jillian Brechbiel et al.
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The PPFIA1-PP2A protein complex promotes trafficking of Kif7 to the ciliary tip and Hedgehog signaling
Yulu C. Liu et al.
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MS-GF plus makes progress towards a universal database search tool for proteomics
Sangtae Kim et al.
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Ciara Metcalfe et al.
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Shirley L. Markant et al.
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Brian D. Cholewa et al.
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PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry
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Frank Goetschel et al.
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Pedro Casado et al.
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Jing-tao Lu et al.
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Polo-like kinase 1 (PLK1) inhibition suppresses cell growth and enhances radiation sensitivity in medulloblastoma cells
Peter S. Harris et al.
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Yan Wang et al.
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Veronica Dudu et al.
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Markus Eberl et al.
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Cooperative Hedgehog-EGFR signaling
Doris Mangelberger et al.
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Dongsheng Gu et al.
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Julia Maria Burkhart et al.
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Kasper Engholm-Keller et al.
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Tamina Seeger-Nukpezah et al.
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Yan Chen et al.
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Junmin Pan et al.
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Putty-Reddy Sudhir et al.
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Alla Maloverjan et al.
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Eric W. Humke et al.
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Yoshinari Asaoka et al.
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Alla Maloverjan et al.
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Hongge Jia et al.
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Oliver Serang et al.
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Sarah C. Goetz et al.
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Barbara Stecca et al.
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Harald Schnidar et al.
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Melanie Philipp et al.
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Hongge Jia et al.
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Marat Gorivodsky et al.
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Graham W. Neill et al.
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JV Olsen et al.
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JL Mullor et al.
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