期刊
CARDIOVASCULAR RESEARCH
卷 116, 期 11, 页码 1820-1834出版社
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvaa222
关键词
Cardio-Oncology; Common pathways in heart failure and cancer; Multicellular and multiorgan mechanisms
资金
- Ricerca di Ateneo/Federico II University grant
- Italian Ministry of Health [GR-2018-12365661]
- National Research, Development and Innovation Office of Hungary (Research Excellence Program - TKP, National Heart Program) [NVKP 16-1-2016-0017, 2019-1.1.1-PIACI-KFI-2019-00367]
- Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within Semmelweis University
- EU-ERANET grant EXPERT
- Incyte Biosciences
- European Research Council [ERC CoG 818715]
- CVON grants from Netherlands Heart Foundation [2014-40, 2017-21, 2017-11, 2018-30]
- ERA-Net-CVD project MacroERA [01KL1706]
- IMI2-CARDIATEAM [821508]
- Associazione Italiana per la Ricerca sul Cancro (AIRC) IG 2016 [19032]
- Leducq Targeted Approaches for Prevention and Treatment of Anthracycline-Induced Cardiotoxicity [09CVD01]
In western countries, cardiovascular (CV) disease and cancer are the leading causes of death in the ageing population. Recent epidemiological data suggest that cancer is more frequent in patients with prevalent or incident CV disease, in particular, heart failure (HF). Indeed, there is a tight link in terms of shared risk factors and mechanisms between HF and cancer. HF induced by anticancer therapies has been extensively studied, primarily focusing on the toxic effects that anti-tumour treatments exert on cardiomyocytes. In this Cardio-Oncology update, members of the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart discuss novel evidence interconnecting cardiac dysfunction and cancer via pathways in which cardiomyocytes may be involved but are not central. In particular, the multiple roles of cardiac stromal cells (endothelial cells and fibroblasts) and inflammatory cells are highlighted. Also, the gut microbiota is depicted as a new player at the crossroads between HF and cancer. Finally, the role of non-coding RNAs in Cardio-Oncology is also addressed. All these insights are expected to fuel additional research efforts in the field of Cardio-Oncology.
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