期刊
CARBOHYDRATE POLYMERS
卷 238, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.116204
关键词
Hyaluronic acid; 3S transition; Cancer; Drug delivery
资金
- National Natural Science Foundation of China [21675091, 21574072, 21874078]
- Taishan Young Scholar Program of Shandong Province [tsqn20161027]
- Major Science and Technology Innovation Project of Shandong Province [2018CXGC1407]
- Key Research and Development Project of Shandong Province [2016GGX102028, 2016GGX102039, 2017GGX20111]
- People's Livelihood Science and Technology Project of Qingdao [166257nsh, 173378nsh]
- Innovation Leader Project of Qingdao [168325zhc]
- Postdoctoral Scientific Research Foundation of Qingdao
- First Class Discipline Project of Shandong Province
In recent years, nano drug delivery system has been widely concerned because of its good therapeutic effect. However, the process from blood circulation to cancer cell release of nanodrugs will be eliminated by the human body's own defense trap, thus reducing the therapeutic effect. In recent years, a 3S transition concept, including stability transition, surface transition and size transition, was proposed to overcome the barriers in delivery process. Hyaluronic (HA) acid has been widely used in delivery of anticancer drugs due to its excellent biocompatibility, biodegradability and specific targeting to cancer cells. In this paper, the strategies and methods of HA-based nanomaterials using 3S theory are reviewed. The applications and effects of 3S modified nanomaterials in various fields are also introduced.
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