4.3 Article

Direct Measurement of the Thermodynamics of Chiral Recognition in Bile Salt Micelles

期刊

CHIRALITY
卷 28, 期 4, 页码 290-298

出版社

WILEY
DOI: 10.1002/chir.22580

关键词

amphiphiles; analytical; chiral resolution; hydrophobic effect; thermodynamics; isothermal titration calorimetry; bile salt; micelle

资金

  1. National Science Foundation [CHE-1153052, CHE-1337721]
  2. Division Of Chemistry
  3. Direct For Mathematical & Physical Scien [1153052, 1337721] Funding Source: National Science Foundation

向作者/读者索取更多资源

Isothermal titration calorimetry (ITC) is shown to be a sensitive reporter of bile salt micellization and chiral recognition. Detailed ITC characterization of bile micelle formation as well as the chiral recognition capabilities of sodium cholate (NaC), deoxycholate (NaDC), and taurodeoxycholate (NaTDC) micelle systems are reported. The H-demic of these bile salt micelle systems is directly observable and is strongly temperature-dependent, allowing also for the determination of Cp-demic. Using the pseudo-phase separation model, G(demic) and TSdemic were also calculated. Chirally selective guest-host binding of model racemic compounds 1,1'-bi-2-napthol (BN) and 1,1'-binaphthyl-2,2'-diylhydrogenphosphate (BNDHP) to bile salt micelles was then investigated. The S-isomer was shown to bind more tightly to the bile salt micelles in all cases. A model was developed that allows for the quantitative determination of the enthalpic difference in binding affinity that corresponds to chiral selectivity, which is on the order of 1 kJ mol(-1). Chirality 28:290-298, 2016. (c) 2016 Wiley Periodicals, Inc.

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