Targeting Tissue Stiffness in Metastasis: Mechanomedicine Improves Cancer Therapy

Tissue stiffening plays a critical role in cancer progression. In this issue of Cancer Cell, Shen et al. demonstrated that highly activated fibroblasts in metastatic colorectal cancer increase tissue stiffness and angiogenesis. Targeting tissue stiffness improves the outcome of anti-angiogenic therapy and prolongs patient survival.