期刊
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN
卷 93, 期 11, 页码 1339-1349出版社
CHEMICAL SOC JAPAN
DOI: 10.1246/bcsj.20200182
关键词
Carboxamides; Amines; Reduction
资金
- Nanyang Technological University (NTU)
- Singapore Ministry of Education [MOE2017-T21-064, MOE2019-T2-1-089]
Carboxamides including lactams are readily available and bench-stable chemical feedstock, and thus their use in chemical synthesis for production of valuable compounds would be an attractive choice in various synthetic endeavors. This review highlights and discusses recent advances on deoxygenative reductive functionalization of carboxamides for the synthesis of alpha-branched amines, that is initiated by controlled single hydride delivery to the amide carbonyl group and terminated by downstream functionalization of the iminium intermediates. The protocols are categorized based on the types of the reduction processes including those with aluminum hydrides, the Schwartz's reagent, transition metal-catalyzed/mediated hydro-silylation, and sodium hydride-iodide composite.
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