期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 177, 期 18, 页码 4113-4133出版社
WILEY
DOI: 10.1111/bph.15201
关键词
vitamin D; cholecalciferol; multiple sclerosis; immune; transcriptome; genetic; supplementation; treatment; therapeutic
资金
- Department of Education, Skills and Employment, Australian Government
- Multiple Sclerosis Research Australia
Initially recognised as an important factor for bone health, vitamin D is now known to have a range of effects on the immune system. Vitamin D deficiency is associated with an increased risk of multiple sclerosis (MS), a chronic immune-mediated demyelinating disease of the CNS. In this review, we explore the links between vitamin D deficiency, MS risk, and disease activity. We also discuss the known immune effects of vitamin D supplementation and the relevance of these observations to the immunopathology of MS. Finally, we review the existing evidence for vitamin D supplementation as an MS therapy, highlighting several recent clinical studies and trials.
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