期刊
BRITISH JOURNAL OF NUTRITION
卷 125, 期 10, 页码 1081-1091出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114520003013
关键词
Non-alcoholic fatty liver; Probiotics; Plant extracts; Intestinal bile acid pathway; Lipid accumulation
资金
- National Key RD of China [2018YFC0311201]
- Heilongjiang province Key Sci. [GA16B201-2]
The study found that administration of probiotics and plant extracts significantly improved blood lipid levels and protected liver structure in patients with non-alcoholic fatty liver disease, especially the combination of L. casei YRL577 with TP had a better effect in improving the condition and regulating gene expression.
Probiotics and plant extracts are considered to prevent the development of non-alcoholic fatty liver disease (NAFLD). The present study explores the effects of using both probiotics and plant extracts on NAFLD. The present study evaluated the effects of plant extracts on lipid droplet accumulation and the growth of probiotics in vitro. A C57BL/6 mouse model was used to examine the effects of probiotics and plant extracts on NAFLD. Body weight and food intake were measured. The levels of serum lipids, oxidative stress and the liver injury index were determined using commercial kits. Haematoxylin and eosin staining, GC and real-time PCR were also used for analysis. The results revealed that administration of Lactobacillus casei YRL577 and L. paracasei X11 with resveratrol (RES) or tea polyphenols (TP) significantly reduced the levels of total cholesterol, TAG and LDL-cholesterol and increased the level of the HDL-cholesterol. The groups of L. casei YRL577 with RES and TP also regulated the liver structure, oxidative stress and injury. Furthermore, L. casei YRL577 with TP exhibited a more positive effect towards improving the NAFLD and increased the concentrations of the butyric acid than other three combined groups. L. casei YRL577 with TP up-regulated the mRNA levels of the farnesoid X receptor and fibroblast growth factor 15 and decreased the mRNA levels of the apical Na-dependent bile acid transporter. These findings showed that L. casei YRL577 + TP-modified genes in the intestinal bile acid pathway improved markers of NAFLD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据