期刊
BRIEFINGS IN FUNCTIONAL GENOMICS
卷 19, 期 5-6, 页码 343-349出版社
OXFORD UNIV PRESS
DOI: 10.1093/bfgp/elaa014
关键词
hallmarks of aging; light resetting; melatonin; mutation rate; transcriptome
资金
- Schweizer National Founds/Founds National Suisse [31003A_152792, 31003A_173048]
- Canton of Fribourg
- Canton of Vaud
- Swiss National Science Foundation (SNF) [31003A_152792, 31003A_173048] Funding Source: Swiss National Science Foundation (SNF)
Aging and circadian rhythms are two biological processes that affect an organism, although at different time scales. Nevertheless, due to the overlap of their actions, it was speculated that both interfere or interact with each other. However, to address this question, a much deeper insight into these processes is necessary, especially at the cellular level. New methods such as single-cell RNA-sequencing (scRNA-Seq) have the potential to close this gap in our knowledge. In this review, we analyze applications of scRNA-Seq from the aging and circadian rhythm fields and highlight new findings emerging from the analysis of single cells, especially in humans or rodents. Furthermore, we judge the potential of scRNASeq to identify common traits of both processes. Overall, this method offers several advantages over more traditional methods analyzing gene expression and will become an important tool to unravel the link between these biological processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据