4.2 Article

Metastatic triple-negative breast cancer: Established and emerging treatments

期刊

BREAST JOURNAL
卷 26, 期 9, 页码 1793-1796

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WILEY
DOI: 10.1111/tbj.13946

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advances; immunotherapy; metastatic; PARP inhibitors; TNBC

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Metastatic triple-negative breast cancer (mTNBC) patients tend to have a poor overall survival. The primary goals of treatment focus on palliation of symptoms and improvement in overall survival (OS). Single-agent sequential chemotherapy with anthracycline or taxane has remained the cornerstone of treatment for many years. The FDA has approved newer agents such as poly-adenosine diphosphate-ribose polymerase (PARP) inhibitors upfront in germline BRCA (gBRCA) 1/2 mutation carriers; atezolizumab and nab-paclitaxel combination frontline in patients with PD-L1 expression > 1%; and sacituzumab govitecan (IMMU-132), an antibody-drug conjugate in heavily pretreated mTNBC patients.

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