期刊
BRAIN RESEARCH
卷 1740, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.brainres.2020.146864
关键词
Retrograde signalling; Axon regeneration; Axonal protein synthesis; Peripheral neuropathies
资金
- NIH/NINDS [K01-NS105879, R01-NS089633, R01NS041596]
- NSF [MCB-1020970]
- Department of Defense, US Army Medical Research and Development [W81XWH-13-1-0308]
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- South Carolina Spinal Cord Injury Research Fund [2018 PD-01]
- UofSC Research Office ASPIRE program
Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate. Axotomized neurons in the periphery can spontaneously mount a regenerative response and reconnect to their denervated target tissues, though this is rarely complete in humans. In contrast, spontaneous regeneration rarely occurs after axotomy in the spinal cord and brain. Here, we concentrate on the mechanisms underlying this spontaneous regeneration in the peripheral nervous system, focusing on events initiated from the axon that support regenerative growth. We contrast this with what is known for axonal injury responses in the central nervous system. Considering the neuropathy focus of this special issue, we further draw parallels and distinctions between the injury-response mechanisms that initiate regenerative gene expression programs and those that are known to trigger axon degeneration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据