Disrupted brain functional network topology in unilateral acute brainstem ischemic stroke

This study aimed to investigate the topological properties of brain functional connectome in unilateral acute brainstem ischemic stroke using graph theory. Fifty-three acute brainstem ischemic stroke patients, consisted of 27 left-sided and 26 right-sided brainstem stroke patients, and 20 age, gender, and education-matched healthy controls (HCs) were recruited to undergo a resting-state functional magnetic resonance imaging (rs-fMRI) scan in this study. Graph theory analyses were then used to examine the group-specific topological properties of the functional connectomes seperately. The unilateral acute brainstem stroke patients and HCs all exhibited small-world brain network topology. The functional connectome of the left brainstem stroke patients showed significant differences in all topological properties while the right brainstem stroke patients showed a significant increase in clustering coefficient Cp (p < 0.001) and local efficiency E-local(p < 0.001), and a significantly decrease in normalized clustering coefficient gamma (p < 0.001) and global efficiency E-global(p < 0.001), suggesting both a shift toward regular networks. At the nodal level, abnormal nodal centralities were mainly observed in the defaut mode network, subcortical network, frontal and occipital lobe. The findings of disrupted topological properties of functional brain networks may help better understanding the disease characterization and innovation in management for acute brainstem ischemic stroke patients.

Automated summary

The study investigated the topological properties of brain functional connectome in unilateral acute brainstem ischemic stroke using graph theory. The patients showed a shift towards a regular network with significant changes in clustering coefficient, local efficiency, normalized clustering coefficient, and global efficiency. Abnormal nodal centralities were mainly observed in the default mode network, subcortical network, frontal and occipital lobe.