期刊
BRAIN BEHAVIOR AND IMMUNITY
卷 91, 期 -, 页码 10-23出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbi.2020.06.014
关键词
Autoimmune diseases; Mental disorders; Comorbidity; Bidirectionality; Human leukocyte antigen; Genome-wide association study
资金
- Lundbeck Foundation, Denmark [R102-A9118, R268-2016-3925, R155-2014-1724]
- Independent Research Fund Denmark [7025-00078B]
- Mental Health Services Capital Region of Denmark
- University of Copenhagen
- Aarhus University
- university hospital in Aarhus
- Lundbeck Foundation
- Stanley Foundation
- Simons Foundation [SFARI 311789]
- NIMH [5U01MH094432-02]
- Novo Nordisk Foundation [NNF14CC0001]
The study confirmed bidirectional association between autoimmune diseases and mental disorders, with significant comorbidity. Several HLA genes were identified to be significantly associated with overall autoimmune disease, along with new candidate genes identified.
Background: Previous studies have indicated the bidirectionality between autoimmune and mental disorders. However, genetic studies underpinning the co-occurrence of the two disorders have been lacking. In this study, we examined the potential genetic contribution to the association between autoimmune and mental disorders and investigated the genetic basis of overall autoimmune disease. Methods: We used diagnostic information from patients with seven autoimmune diseases and six mental disorders from the Danish population-based case-cohort sample (iPSYCH2012). We explored the epidemiological association using survival analysis and modelled the effect of polygenic risk scores (PRSs) on autoimmune and mental diseases. Genetic factors were investigated using GWAS and imputed HLA alleles in the iPSYCH cohort. Results: Of 64,039 individuals, a total of 43,902 (68.6%) were diagnosed with mental disorders and 1383 (2.2%) with autoimmune diseases. There was a significant comorbidity between the two disease classes (P = 2.67 x 10(-7), OR = 1.38, 95%CI = 1.22-1.56), with an overall bidirectional association, wherein individuals with autoimmune diseases had an increased risk of subsequent mental disorders (HR = 1.13, 95%CI: 1.07-1.21, P = 7.95 x 10(-5)) and vice versa (HR = 1.27, 95%CI = 1.16-1.39, P = 8.77 x 10(-15)). Adding PRSs to these adjustment models did not have an impact on the associations. PRSs for autoimmune diseases were only slightly associated with increased risk of mental disorders (HR = 1.01, 95%CI: 1.00-1.02, p = 0.038), whereas PRSs for mental disorders were not associated with autoimmune diseases overall. Our GWAS highlighted 12 loci on chromosome 6 (minimum P = 2.74 x 10(-36), OR = 1.80, 95% CI: 1.64-1.96), which were implicated in gene regulation through bioinformatic functional analyses, thereby identifying new candidate genes for overall autoimmune disease. Moreover, we observed 20 human leukocyte antigen (HLA) alleles strongly associated, either positively or negatively, with overall autoimmune disease, but we did not find significant evidence of their associations with overall mental disorders. A GWAS of a comorbid diagnosis of an autoimmune disease and a mental disorder identified a genome-wide significant locus on chromosome 7 as well (P = 1.43 x 10(-8), OR = 10.65, 95%CI = 3.21-35.36). Conclusions: Our findings confirm the overall comorbidity and bidirectionality between autoimmune diseases and mental disorders and identify HLA genes which are significantly associated with overall autoimmune disease. Additionally, we identified several new candidate genes for overall autoimmune disease and ranked them based on their association with the investigated diseases.
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