期刊
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
卷 21, 期 1, 页码 1-4出版社
ASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVO
DOI: 10.17305/bjbms.2020.4908
关键词
HER2; targeted therapy; mutations; amplification
Functional activation of HER2 has been shown to strongly promote carcinogenesis, with HER2 gene amplification in breast and gastric/gastroesophageal junction carcinomas being well-documented. Recently discovered somatic HER2 gene mutations have emerged as a novel predictive biomarker for HER2-directed therapies, showing sensitivity to targeted agents in clinical trials.
Functional activation of human epidermal growth factor receptor 2 (HER2) has been shown to strongly promote carcinogenesis, leading to the investigation of HER2-directed agents in cancers with HER2 genomic alterations. This has been best documented in the context of HER2 gene amplification in breast and gastric/gastroesophageal junction carcinomas for which several HER2-directed agents are available and have become a part of standard treatment regimens. Somatic! HER2 gene mutations have been recently described at low frequency in a variety of human cancers and have emerged as a novel predictive biomarker for HER2-directed therapies. Preclinical data also indicate that activating HER2 mutations are potent oncogenic drivers in a manner that is analogous to HER2 amplification. HER2 mutations may clinically confer sensitivity to HER2-directed agents as recently shown in a phase II clinical trial with antibody-drug conjugate against HER2 trastuzumab deruxtecan in patients with non-squamous non-small cell lung carcinoma.
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