期刊
BONE MARROW TRANSPLANTATION
卷 56, 期 1, 页码 20-29出版社
SPRINGERNATURE
DOI: 10.1038/s41409-020-0974-6
关键词
-
The study showed that allo-HCT from >= 2 HLA allele MMUD in acute leukemia patients resulted in acceptable leukemia-free survival and refined GVHD-free, relapse-free survival, although HLA-DR mismatch was identified as a poor prognostic factor.
A mismatched unrelated (MMUD) donor represents an alternative therapeutic option for patients who need allogeneic hematopoietic cell transplantation (allo-HCT) and do not have a human leukocyte antigen (HLA) matched donor. We studied outcomes of patients with acute leukemia transplanted from >= 2 HLA allele MMUD. The study population consisted of 465 patients. The median follow-up period was 63 and 75 months in the AML and ALL groups, respectively. The incidence of grade II-IV and grade III-IV acute (a) graft-versus-host disease (GVHD) during the first 100 days was 37% and 16%, respectively. Total and extensive chronic (c) GVHD rates at 2 years were 38% and 17%, respectively. In the entire population, the 5-year relapse incidence (RI), non-relapse mortality (NRM), leukemia-free survival (LFS), overall survival and refined GVHD-free, relapse-free survival (GRFS) was 33%, 31%, 37%, 41%, and 27%, respectively. In the multivariate analysis, HLA-DR mismatch was a poor prognostic factor, giving a significantly higher NRM [hazard ratio (HR), 1.67,p = 0.02]; poorer LFS (HR, 1.42,p = 0.03); OS (HR, 1.46,p = 0.03) and higher aGVHD grade II-IV (HR, 1.46,p = 0.05). In this study, allo-HCT from <= 6/8 HLA allele MMUD in acute leukemia patients resulted in acceptable LFS and refined GRFS. HLA-DR mismatch was a poor prognostic factor.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据