期刊
BMC PUBLIC HEALTH
卷 20, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12889-020-09011-x
关键词
Mn; Occupation; Dyslipidaemia; Triglycerides
资金
- National Natural Science Foundation of China [81860573]
- Guangxi Natural Science Fund for Innovation Research Team [2017GXNSFGA198003]
BackgroundManganese (Mn) participates in lipid metabolism. However, the associations between Mn exposure and dyslipidaemia is unclear.MethodsThis was a cross-sectional study. Data were collected from the 2017 the Mn-exposed workers healthy cohort (MEWHC). Finally, 803 occupationally Mn-exposed workers included in the study. The workers were divided into two groups. The grouping of this study was based on Mn-Time Weighted Averages (Mn-TWA). The high-exposure group included participants with Mn-TWA greater than 0.15mg/m(3). The low-exposure group included participants with Mn-TWA less than or equal to 0.15mg/m(3). Mn-TWA levels and dyslipidaemia were assessed.ResultsAfter adjustment for seniority, sex, cigarette consumption, alcohol consumption, high-fat diet frequency, medicine intake in the past two weeks, egg intake frequency, drinking tea, WHR, and hypertension, Mn-TWA levels was negatively correlated with high triglycerides (TG) risk in workers overall (OR=0.51; 95% CI: 0.36, 0.73; p< 0.01). The results of males and females were consistent (OR=0.53; 95% CI: 0.34, 0.81; p< 0.01) and (OR=0.47; 95% CI: 0.24, 0.94; p< 0.01), respectively. By performing interactions analyses of workers overall, we observed no significant interactions among confounders. Mn-TWA levels and pack-years on high TG risk (relative excess risk for the interactions (RERI=2.29, 95% CI: -2.07, 6.66), (RERI)=2.98, 95% CI: -2.30, 8.26). Similarly, smoking status, drinking status, high-fat diet frequency, and Waist-to-Hip Ratio (WHR) showed non-significant interactions with Mn-TWA levels on high TG risk.ConclusionsThis research indicates that high Mn exposure was negatively related to high TG risk in workers.
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