In this issue of Blood, Fagnan et al investigate the genetic and transcriptional landscape of 33 acute erythroleukemia (AEL) patients and propose a transcriptome-based space that helps distinguish AEL from other myeloid leukemias.1 They also provide intriguing evidence for leukemic transformation in AEL being a result of aberrant transcription factor expression impinging on GATA1 functions in erythropoiesis.
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