期刊
BLOOD
卷 136, 期 12, 页码 1394-1401出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood.2019004158
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资金
- National Institutes of Health, National Institute of Allergy and Infectious Diseases [R01 AI128589]
- National Institutes of Health, National Cancer Institute [R35 CA210043]
Vitamin C serves as a cofactor for Fe(II) and 2-oxoglutarate-dependent dioxygenases including TET family enzymes, which catalyze the oxidation of 5-methylcytosine into 5-hydroxymethylcytosine and further oxidize methylcytosines. Loss-of-function mutations in epigenetic regulators such as TET genes are prevalent in hematopoietic malignancies. Vitamin C deficiency is frequently observed in cancer patients. In this review, we discuss the role of vitamin C and TET proteins in cancer, with a focus on hematopoietic malignancies, T regulatory cells, and other immune system cells.
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