4.4 Article

Markedly increased prevalence of migraine headaches in adolescents with bipolar disorder

期刊

BIPOLAR DISORDERS
卷 23, 期 3, 页码 255-262

出版社

WILEY
DOI: 10.1111/bdi.12972

关键词

adolescents; bipolar disorder; headache; migraine

资金

  1. Heart and Stroke Foundation of Canada
  2. Deutscher Akademischer Austauschdienst [PROMOS]
  3. University of Toronto Department of Psychiatry
  4. Fondation Brain Canada
  5. Ontario Institute of Research, Innovation and Technology
  6. National Institute of Mental Health
  7. Michael Albert Garron Foundation
  8. Brain and Behavior Research Foundation
  9. Canadian Institutes of Health Research
  10. Great Gulf Foundation

向作者/读者索取更多资源

There is a high prevalence of migraines among adolescents with BD compared to healthy controls, with similar correlates to those found in adults, including the association with the depressive polarity of BD. Future prospective studies are needed to evaluate the temporal associations between migraines and mood symptoms, as well as the neurobiological and cardiovascular underpinnings of these associations.
Objective There is substantial evidence of increased prevalence of migraines, and negative psychiatric correlates of migraines, in adults with bipolar disorder (BD). Given the paucity of data on this topic in youth, we investigated the prevalence and correlates of migraine in a large sample of adolescents with BD. Method The study included 165 adolescents with BD-I, -II, or -not otherwise specified (NOS), diagnosed via the KSADS-PL semi-structured interview, and 89 healthy controls (HCs). Non-migraine headache and migraine headache was evaluated using the validated ID-Migraine 3-item screener. Results Although the prevalence of non-migraine headaches did not differ between adolescents with BD (24.2%) and HCs (32.6%;P = .15), migraine was significantly more prevalent among adolescents with BD (38.2%) compared to HCs (3.4%; adjusted odds ratio 14.76, 95% confidence interval 4.39-49.57;P < .001). Within BD, migraine was associated with female sex, BD-II/-NOS subtype, less severe worst past functioning, higher past depression severity, higher self-reported affective lability, higher body mass index, and less use of lithium and second-generation antipsychotics. Discussion Migraine is much more prevalent among adolescents with BD compared to HCs; the magnitude of this association exceeds what has been reported in adult samples. Correlates of migraine in youth BD are similar to those found for adults, including the link with the depressive polarity of BD. Future prospective studies are warranted to evaluate temporal associations between migraine and mood symptoms, and to evaluate neurobiological and cardiovascular underpinnings of these associations.

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