期刊
BIOSENSORS & BIOELECTRONICS
卷 159, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2020.112202
关键词
Dual mode; Sensing platform; Molecular imprinted polymers; Bovine hemoglobin; ZnCdS/ZnIn2S4
类别
资金
- National Natural Science Foundation of China [51873136]
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [18KJA150008]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX18_2499]
- project of scientific and technologic infrastructure of Suzhou [SZS201708]
- Natural Science Foundation of Jiangsu Province [BK20181428]
The construction of dual mode sensor has gained tremendous attention due to its high accuracy and sensitivity compared with a single-response system. Herein, a novel dual mode sensing platform based on a 3-dimensional (3D) ZnCdS/ZnIn2S4 double-shelled dodecahedral cages (DSDCs) is fabricated as the electrochemical (EC) - photoelectrochemical (PEC) multifunctional signal amplification matrix for the highly selective detection of bovine hemoglobin (BHb). To achieve simple and fast detection of BHb, Au@Cu2O and SnO2/SnS2 are acted as EC - PEC signal indicators, respectively. More interestingly, the electroactive Au@Cu2O and photoactive SnO2/SnS2 are assembled on the 3D ZnCdS/ZnIn2S4 DSDCs, which could effectively increase the electron transfer process, consequently amplifying the readout of the dual mode responses. Besides, polydopamine (PDA) is used as a monomer for protein imprinting. Under the optimized conditions, the dual mode sensor exhibits a wide linear concentration range from 10(-19) mg mL(-1 )to 10(-1) mg mL(-1) with a low detection limit 6.5 x 10(-2)(0) mg mL(-1). Furthermore, the excellent selectivity, stability and acceptable reproducibility of the designed sensor will offer an alternation for the detection of other biomacromolecules in clinic diagnosis field.
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