期刊
BIOSENSORS & BIOELECTRONICS
卷 157, 期 -, 页码 -出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2020.112168
关键词
Lateral flow test strip; Sensor; Multiplexing; Rapid diagnostics; On site
类别
资金
- National Key Research and Development Program of China [2018YFC1602505, 2018YFC1602202, 2018YFC1602203]
- National Natural Science Foundation of China [31760485, 31471648, 31901780]
- Interdisciplinary Innovation Fund of Natural Science, Nanchang University [9166-27060003-ZD01]
Conventional lateral flow test strip (LFTS) sensors are insufficiently accurate and reliable due to their single-target detection with limited sample information in a single test. The increasing demand for the simultaneous determination of multiple analytes has recently been accelerating the rapid development of high-throughput and multiplexed LFTS sensing technologies. In this contribution, we systematically summarize the recent achievements on the design, development, and application of multiplexed LFTS sensors for improved rapid on-site diagnostics. The discussion focuses on emerging design strategies to increase multiplexing capacity for enhancing analytical efficiency and precision. As a proof-of-concept, several typical examples are presented. The advantages and disadvantages of such approaches are critically analyzed. Finally, we briefly discuss the current challenges and future perspectives.
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