期刊
BIOORGANIC CHEMISTRY
卷 99, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2020.103791
关键词
Protozoa; Acanthamoeba; N-acyl quinolin-2(1H)-ones; Trophozoites; Cysts
资金
- Organic Chemistry Department, Universidad de La Laguna
- RICET (Redes Tematicas de Investigacion Cooperativa, FIS) [RD16/0027/0001]
- Agustin de Betancourt Program
A collection of N-substituted quinolin-2(1H)-ones were screened against a panel of clinically relevant protozoa (Leishmania, Trypanosoma and Acanthamoeba). Three quinolin-2(1H)-one compounds were identified as selective anti-Acanthamoeba agents. Further assessment revealed that these compounds were active against both trophozoite and cyst forms of A. castellanii Neff, and caused protozoa death via apoptosis. The data presented herein identify N-acyl quinolin-2(1H)-ones as a promising new class of selective anti-Acanthamoeba agents.
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