期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 30, 期 20, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2020.127497
关键词
Neovibsanin; Phenylbutadiene dimer; Neurite-outgrowth promoting activity; Neuritogenic activity; Structure merging method
资金
- Nagai memorial research scholarship from the pharmaceutical society of Japan
- Japan science society [2018-3008]
A hybrid compound consisting of neovibsanin and trans-banglene was designed according to a structure merging method and synthesized via a sequence of key steps including a Diels-Alder cycloaddition, stereoselective alkynylation, and intramolecular oxa-Michael addition reaction. The biological activity of the synthetized acetal compound and its hemiacetal analogue was investigated in PC12 cells. These studies revealed that the designed hybrid compounds displayed neuritogenic activity. Furthermore, a relatively strong neurite outgrowth promoting activity was observed in the presence of NGF. These results suggest that the designed hybrid compound exhibited a dual activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据