期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 30, 期 20, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2020.127491
关键词
Artemisinin; Trioxanes; Trypanosoma cruzi; Leishmania donovani; Tropical neglected diseases
资金
- Consejo Nacional de Investigaciones Cientificas y Tecnicas, Agencia Nacional de Promocion Cientifica y Tecnologicaa (FONCyT PICT) [2015-0539, 2018-180, 2016-1069, 2017-2096]
- Universidad Nacional de Rosario [BIO503]
- UK Research and Innovation via the Global Challenges Research Fund [MR/P027989/1]
- Global Challenges Research Fund (GCRF), Neglected Tropical Diseases Network
- MRC [MR/P027989/1] Funding Source: UKRI
A series of synthetic 1,2,4-trioxanes related to artemisinin was tested against L. donovani and T. cruzi parasites. This screening identified some active compounds, with key common structural features. Interestingly, these selected trioxanes were efficient against both parasites, and achieved antiparasitic activities comparable or superior than those presented by the corresponding reference drugs, artemisinin and artesunate. This study represents the first example of synthetic trioxanes evaluated on T. cruzi and provides possible candidates for developing new drugs for the treatment of leishmaniasis and Chagas disease.
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