期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 30, 期 12, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2020.127192
关键词
Tuberculosis; DprE1; Inhibitor; 2,3-Dihydrobenzo [b] [1,4]dioxin; Minimum inhibitory concentration
资金
- GlaxoSmithKline/University of Strathclyde Industrial PhD program
The identification of a novel series of DprE1 inhibitors based on a 2((2,3-dihydrobenzo [b][1,4]dioxin-6-yl) amino)-N-phenylpropanamide scaffold is described herein. SAR exploration around the HTS hit 1 led to the identification of multiple analogues with potent DprE1 inhibition and good whole-cell antimycobacterial activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据