期刊
BIOMOLECULES & THERAPEUTICS
卷 29, 期 1, 页码 52-57出版社
KOREAN SOC APPLIED PHARMACOLOGY
DOI: 10.4062/biomolther.2020.062
关键词
Fumonisin B1; Catalase; Glutathione peroxidase1; Sphingosine; Sphinganine
资金
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT, & Future Planning (MRC) [2010-0029355]
The study found that after FB1 treatment, Gpx1/Cat KO mice had higher levels of TBARS and Sa in serum, but lower levels of ALT, So-1-P, and Sa-1-P; while Sa was elevated in both Gpx1/Cat KO mice and wild type mice, lower levels of So and Sa were observed in kidney and liver tissues of Gpx1/Cat KO mice. Paradoxically, FB1-induced cellular apoptosis and necrosis were accelerated in Gpx1/Cat KO mice under oxidative stress.
Fumonisin B1 (FB1) structurally resembles sphingolipids and interferes with their metabolism leading to sphingolipid dysregulation. We questioned if FB1 could exacerbate liver or kidney toxicities in glutathione peroxidase 1 (Gpx1) and catalase (Cat) knockout mice. While higher serum levels of thiobarbituric acid reactive substances (TBARS) and sphinganine (Sa) were measured in Gpx1/Cat knockout mice (Gpx1/Cat KO) than wild type mice after 5 days of FB1 treatment, serum levels of alanine aminotransferase (ALT), sphingosine-1 phosphate (So-1-P), and sphinganine-1 phosphate (Sa-1-P) were found to be relatively low. Although Sa was highly elevated in Gpx1/Cat KO mice and wild mice, lower levels of So and Sa were found in both the kidney and liver tissues of Gpx/Cat KO mice than wild type mice after FB1 treatment. Paradoxically, FB1-induced cellular apoptosis and necrosis were hastened under oxidative stress in Gpx1/Cat KO mice.
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