期刊
BIOMOLECULAR NMR ASSIGNMENTS
卷 14, 期 2, 页码 309-315出版社
SPRINGER
DOI: 10.1007/s12104-020-09968-1
关键词
KKT4; Kinetoplastid; Kinetochore; Trypanosomes; NMR resonance assignments
资金
- Boehringer Ingelheim Fonds
- Wellcome Trust Senior Research Fellowship [210622/Z/18/Z]
- European Molecular Biology Organisation Young Investigator Program
- University of Oxford Wellcome Institutional Strategic Support Fund
- John Fell Fund
- Engineering and Physical Sciences Research Council [EP/R029849/1]
- Edward Penley Abraham Cephalosporin Fund
- Wellcome Trust [210622/Z/18/Z] Funding Source: Wellcome Trust
- EPSRC [EP/R029849/1] Funding Source: UKRI
KKT4 is a kinetoplastid-specific microtubule-binding kinetochore protein that lacks significant similarity to any known kinetochore or microtubule-binding proteins. Here we present the(1)H,C-13 and(15)N resonance assignments for several fragments from the microtubule-binding domain of KKT4 (KKT4(115-343)) fromTrypanosoma brucei. These assignments provide the starting point for detailed investigations of the structure, dynamics and interactions of the microtubule-binding region of KKT4.
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