A hybrid electrically-and-piezoelectrically driven micromixer built on paper for microfluids mixing

This study aims to explore the channel patterns and the characteristic parameters of the zigzag microchannel based on microfluidic paper-based analytical devices (mu PADs), in which the mixing efficiency and speed can be greatly enhanced. Better mixing of the solutions was obtained by adding a simple directing electric field to the optimized structure of the zigzag microchannel on paper-based chips instead of the traditional complex devices. A higher mixing efficiency was reached when the direct-current (DC) power supply reached 20 V. Meanwhile, a piezoelectric transducer (PZT) driver was used in the mixing experiment with the paper-based zigzag microchannel. The results show that the mixing efficiency reached a maximum value when the input voltage and frequency were 30 V and 150 Hz, respectively. These paper-based devices meet the requirements of the biochemical analysis field because they are low cost, easy to operate, and have high efficiencies, giving them good prospects for future applications.