期刊
BIOMATERIALS
卷 251, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.120092
关键词
Near-infrared II; Photoacoustic imaging; Photothermal therapy; Multidrug-resistant bacterial infections; Theranostics
资金
- National Key Research and Development Program of China: Scientific and Technological Innovation Cooperation of Mainland and Macao [2017YFE0120000]
- Natural Science Foundation of China [91859117, 81771906, 81827807, 81901812, 81527901, 21875218]
- CAS key laboratory of health informatics [2011DP173015]
- Science and Technology Innovation Fund of Shenzhen [JCYJ20170818161918918, JCYJ20190812163614809]
- Shenzhen Key Laboratory of Ultrasound Imaging and Therapy [ZDSYS201802061806314]
- High-Level University Construction Project [A1-AFD018171Z11070]
- Research Fund for Young Teacher Training Project of Sun Yat-sen University [20ykpy42]
- China Postdoctoral Science Foundation [2019M653129]
Multidrug-resistant Staphylococcus aureus (MRSA) seriously endanger human health. The development of efficient methods to eliminate the infections and monitor the treatment process are of great significance. Nearinfrared-II (NIR-II) photoacoustic (PA) imaging and photothermal therapy (PTT) are highly integrated theranostic platforms with superior performance including a low imaging background, increased tissue penetration depth, and high photothermal threshold. Herein, we report an activatable near-infrared II (NIR-II) photo-theranostic strategy using miniature Au/Ag nanorods (NRs) for the photochemical synergistic therapy of MRSA infections and in situ monitoring of the treatment progress. Au/Ag NRs were efficiently activated by ferricyanide solution and allowed to continuously release free Ag+ to eliminate MRSA, triggering NIR-II photothermal and PA performance enhancement. The activated NIR-II photothermal effect in turn accelerated the release of free Ag+ from Au/Ag NRs for the synergistic elimination of gram-positive Staphylococcus aureus and promoted wound healing. No photothermal damages or free Ag+-induced side effects were observed in treated mice. After synergistic treatment, a 20-fold NIR-II PA signal increase with a maximum signal-to-noise measurement of 9.5 was observed between the implanted site and normal tissue, enabling sensitive monitoring of Ag+ release process. The prepared Au/Ag NRs were stable and biocompatible, showing great potential for activatable NIR-II phototheranostic application.
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